Mefloquine

Recommended for:

a) Prevention of choroquine resistant malaria
b) Treatment of chloroquine resistant malaria

Dose:

a) Prevention – 250 mg tablet, once a week starting one week prior to trip, during trip and for four weeks after return.
b) Treatment – 250 mg tablet, 5 tablets all at once for mild –moderate malaria and seek medical attention.

Take with food:

Yes

Pregnancy risk:

Avoid if pregnant

Alcohol drinking:

OK

Breast feeding risk:

Avoid if breast feeding

Contraindications:

Allergy to mefloquine or aminoquinoline compounds (quinine/quinidine)
Seizures
Heart rhythm disturbances
Psychiatric illness (depression/schizophrenia)

Common Side effects:

Rash
Nausea, vomiting, diarrhea and abdominal cramps/pains
Headache, fever, chills
Muscle pains, body aches
Ringing in the ears, dizzines

Common Drug interactions:

Vaccinations should be delayed at least 3 days prior to mefloquine.
Decreases blood levels of phenytoin, valproic acid, carbamazepine, phenobarbital.
Interaction with quinine/quinidine can result in heart rhythm abnormalities and seizures.

Discuss above and other medication interactions with your pharmacist.

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